Premium SELANK Research Peptide — High-Purity ACTH(4-10) Analog for Laboratory Use

Product Overview

Premium SELANK is a research‑grade synthetic heptapeptide derived from the N‑terminal fragment (4‑10) of adrenocorticotropic hormone (ACTH). It is supplied as a sterile lyophilized powder in sealed vials. Each package contains ten vials, with each vial holding 10mg of the research compound. This product is manufactured exclusively for scientific investigation and in vitro laboratory experimentation.

Key Specifications at a Glance:

• Quantity: 10mg per vial, 10 vials per pack

• Form: Lyophilized (freeze‑dried) powder

• Purity: ≥98% verified by third‑party testing

• Molecular Formula: C₃₆H₅₃N₉O₁₀

• Molecular Mass: 751.83

• CAS Number: 220501-39-7

• Sequence: Met‑Glu‑His‑Phe‑Pro‑Gly‑Pro (MEHFPGP)

• Synonyms: Selank, ACTH (4-10) analog, TP‑7

• Research Use Only: Not for human or animal consumption

Understanding SELANK: The Research Context

SELANK is a synthetic research peptide that belongs to the family of ACTH(4‑10) analogs. The parent molecule, ACTH(4‑10) (Met‑Glu‑His‑Phe‑Arg‑Trp‑Gly), is a fragment of adrenocorticotropic hormone known to influence learning, memory, and anxiety‑like behaviors in laboratory models. SELANK is a stabilized analog of this fragment, designed to enhance metabolic stability while preserving the core bioactive sequence. Structurally, it is closely related to SEMAX but differs in the oxidation state of the methionine residue and the composition of the stabilizing C‑terminal tail.

Key Research Interests:

• Anxiolytic (anxiety‑reducing) mechanisms

• Neuropeptide stability and structure‑activity relationships

• Serotonergic and dopaminergic system modulation

• Neuroprotection and stress‑response pathways

• In vitro cell culture and neuropharmacology

Researchers utilize SELANK in controlled laboratory settings to investigate the molecular pathways underlying anxiety, stress resilience, and emotional regulation. The peptide is of particular interest to investigators focused on neuropsychopharmacology, stress biology, and the development of stable ACTH fragments for basic research.

The Significance of ACTH(4‑10) Research:
ACTH(4‑10) is a naturally occurring fragment of adrenocorticotropic hormone that has been shown to affect behavior, learning, and emotional responses in animal models. However, it is rapidly degraded by enzymes, limiting its utility in laboratory research. SELANK was developed to overcome this limitation:

• Enhanced stability: Chemical modifications protect the peptide from enzymatic breakdown

• Retained bioactivity: The core ACTH(4‑7) sequence (Met‑Glu‑His‑Phe) is preserved

• Anxiolytic selectivity: Focuses on stress‑related and emotional pathways without hormonal side effects

SELANK vs. SEMAX: A Research Comparison

Researchers often compare SELANK and SEMAX, as both are ACTH(4‑10) analogs with distinct properties.

Choosing Between SELANK and SEMAX:

• SELANK — Preferred for research into anxiety, stress, emotional regulation, and serotonergic pathways

• SEMAX — Preferred for research into cognition, memory, BDNF expression, and dopaminergic systems

Both peptides share the same amino acid sequence (MEHFPGP) but differ in the oxidation state of the methionine residue. SELANK contains methionine in its native, non‑oxidized form, which is reflected in its lower molecular mass and distinct biological profile.

Third‑Party Testing and Quality Assurance

Every batch of Premium SELANK undergoes rigorous independent analytical testing to verify identity, purity, and consistency. This third‑party testing ensures that researchers receive a product that meets strict quality specifications before it is approved for release.

The testing process includes:

• Identity verification through mass spectrometry

• Purity analysis using high‑performance liquid chromatography (HPLC)

• Batch‑to‑batch consistency checks

• Residual solvent analysis to confirm complete lyophilization

With a verified purity of ≥98% as confirmed by HPLC, SELANK meets the high standards required for serious laboratory research applications. Each vial contains only the lyophilized research compound with no unnecessary additives, fillers, or excipients. Batch‑specific Certificates of Analysis (CoA) are available upon request.

Chemical and Physical Properties

Molecular Characteristics

SELANK is a synthetic heptapeptide (7 amino acids) with the sequence Met‑Glu‑His‑Phe‑Pro‑Gly‑Pro, containing methionine in its native (non‑oxidized) form.

Detailed Molecular Information:

• Molecular Formula: C₃₆H₅₃N₉O₁₀

• Molecular Mass: 751.83 daltons

• CAS Number: 220501-39-7

• Sequence: Met‑Glu‑His‑Phe‑Pro‑Gly‑Pro (MEHFPGP)

• Purity: ≥98% (HPLC)

• Appearance: White to off‑white lyophilized powder

• Isoelectric Point (pI): 5.38

Structural Features:

• Heptapeptide (7 amino acids)

• Contains methionine (no sulfur oxidation)

• Includes histidine and phenylalanine (aromatic residues)

• Proline residues contribute to conformational rigidity

• Linear peptide (no disulfide bridges)

Unlike SEMAX, SELANK lacks the methionine sulfoxide modification. This absence of an oxygen atom on the methionine sulfur reduces molecular mass and may influence receptor interactions and metabolic stability.

Physical Form and Storage

The product is supplied as a lyophilized (freeze‑dried) powder within a sterile, sealed vial. Lyophilization preserves the chemical integrity of the peptide by removing water content while maintaining the compound’s structure.

Recommended Storage Conditions:

• Store lyophilized powder at -20°C (-4°F) or below for long‑term preservation

• Protect from light exposure

• Keep desiccated to prevent moisture absorption

• Allow vial to reach room temperature before opening to avoid condensation

• Avoid repeated freeze‑thaw cycles once reconstituted

Stability Considerations:
The native methionine residue in SELANK can be susceptible to oxidation over time, especially if exposed to air, light, or oxidizing agents. Minimize air exposure and store under inert gas if possible for long‑term storage. Lyophilized powder stored at -20°C in a desiccated, airtight container is stable for up to 24 months.

Once reconstituted with an appropriate sterile solvent, the solution should be used promptly according to laboratory protocols or aliquoted and frozen at -80°C.

Intended Use and Regulatory Status

Research Use Only

SELANK is classified as a research chemical and is intended exclusively for laboratory and in vitro experimentation. This designation means the product is sold strictly for:

• In vitro testing — experiments conducted in controlled laboratory environments

• Cell culture studies — investigating anxiolytic mechanisms and neurotransmitter pathways

• Stress and anxiety research — studying serotonergic and dopaminergic modulation

• Neuropeptide stability studies — structure‑activity relationship (SAR) analysis

• Analytical research — chemical analysis and characterization studies

• Scientific investigation — basic research into ACTH(4‑10) analog biology

Important Regulatory Notice

This product is not a drug, food, cosmetic, or medical device. Bodily introduction of any kind into humans or animals is strictly forbidden by law. The product should only be handled by licensed, qualified professionals working in appropriate laboratory facilities.

The supplier is a chemical supplier, not a compounding pharmacy or outsourcing facility under Sections 503A or 503B of the Federal Food, Drug, and Cosmetic Act. All product information provided is for educational and research purposes only and does not constitute medical advice or clinical recommendations.

Handling and Safety Guidelines

Professional Handling Required

SELANK should only be handled by trained laboratory personnel wearing appropriate personal protective equipment (PPE), including:

• Laboratory coat

• Nitrile gloves

• Safety goggles or face shield

• Appropriate respiratory protection if aerosolization is possible

Reconstitution Protocol

For laboratory use, the lyophilized powder should be reconstituted with a sterile, compatible solvent. Standard practice includes:

1. Allow the sealed vial to reach room temperature — approximately 15-30 minutes

2. Clean the rubber stopper with an alcohol swab

3. Add the calculated volume of solvent to achieve desired concentration

4. Gently swirl or roll the vial between palms — do not shake vigorously to avoid foaming

5. Allow complete dissolution before use — this typically takes 2-5 minutes

Reconstitution Example for SELANK 10MG:
For researchers needing a 5mg/mL working solution, add 2mL of sterile solvent to the 10mg vial. For a 10mg/mL solution, add 1mL of solvent. For a 2mg/mL solution, add 5mL of solvent. Always verify calculations before proceeding with experiments.

Solvent Considerations:
SELANK is water‑soluble. Researchers should determine the appropriate solvent based on their specific experimental protocol. Common options include sterile water for injection, bacteriostatic water, or buffered solutions such as phosphate‑buffered saline (PBS) at neutral pH.

Disposal Considerations

Dispose of SELANK and any contaminated materials in accordance with federal, state, and local regulations for chemical waste disposal. Do not dispose of in regular trash or down drains unless permitted by local guidelines.

Research Applications

SELANK is used in various laboratory research contexts, primarily focused on anxiety, stress, and neuropeptide signaling. Typical applications include:

Anxiolytic Mechanism Studies:
The primary research interest in SELANK revolves around its anxiety‑reducing properties. Researchers use SELANK to study:

• Serotonin (5‑HT) receptor expression and function

• GABAergic system modulation

• Stress‑induced changes in neurotransmitter levels

• Behavioral models of anxiety and emotional learning

Serotonergic and Dopaminergic System Research:
SELANK has been shown to influence monoamine pathways. Applications include:

• Serotonin turnover and metabolite measurements

• Dopamine release in stress‑relevant circuits

• Monoamine oxidase (MAO) activity

• Receptor binding and signaling studies

Stress and HPA Axis Research:
Unlike ACTH itself, SELANK. does not stimulate cortisol release but may modulate stress responses. Research applications include:

• Corticosterone regulation in stress models

• Hypothalamic‑pituitary‑adrenal (HPA) axis feedback

• Stress‑induced gene expression changes

• Neuroendocrine adaptation pathways

Cell Culture Investigations:
Researchers use SELANK in controlled cell culture systems to study:

• Neuronal survival under stress conditions

• Astrocyte inflammatory responses

• Neuropeptide stability and degradation

• Receptor binding and second messenger activation

Structure‑Activity Relationship (SAR) Analysis:
As a stabilized ACTH(4‑10) analog, SELANK is valuable for:

• Comparing the effects of methionine oxidation state (SELANK vs. SEMAX)

• Identifying minimal active sequences for anxiolytic activity

• Understanding the role of the C‑terminal tail in stability and efficacy

Researchers should design their experimental protocols based on peer‑reviewed literature and established laboratory practices specific to ACTH(4‑10) analogs.

What Makes This Product Different

Anxiolytic‑Focused ACTH(4‑10) Analog

Unlike SEMAX, which is primarily associated with cognitive enhancement and BDNF modulation, SELANK is specifically studied for its anxiety‑reducing and stress‑resilience properties. This focus makes SELANK a valuable research tool for investigators studying emotional regulation and neuropsychopharmacology.

Native Methionine Configuration

SELANK contains methionine in its native, non‑oxidized form, distinguishing it from SEMAX. (which contains methionine sulfoxide). This structural difference may influence receptor interactions, metabolic stability, and biological activity.

Well‑Characterized Neurotransmitter Effects

Research has demonstrated that SELANK. influences both serotonergic and dopaminergic systems, making it a useful tool for studying monoamine pathways in the context of anxiety and stress.

Rigorous Quality Control

Unlike research chemicals sold without verification, SELANK comes with documented third‑party testing for every batch, including HPLC purity analysis and mass spectrometry identity confirmation.

Batch Traceability

Each package of SELANK includes batch identification numbers that allow researchers to trace their material back to original manufacturing and testing records. This traceability is essential for reproducible research and quality documentation.

Frequently Asked Questions for Researchers

What is the purity level of SELANK?

Each batch is tested to verify purity of ≥98% via HPLC, with identity confirmed by mass spectrometry. Individual certificates of analysis are available upon request.

What is the significance of the CAS number 220501-39-7?

The CAS number is a unique identifier for SELANK, allowing researchers to verify they are working with the correct chemical compound when ordering or referencing the peptide in publications.

What is the amino acid sequence of SELANK?

The sequence is Met‑Glu‑His‑Phe‑Pro‑Gly‑Pro (MEHFPGP). It is identical to SEMAX in primary sequence but differs in the oxidation state of methionine.

How does SELANK differ from SEMAX?

SELANK and SEMAX share the same amino acid sequence but differ in the oxidation state of the methionine residue. SEMAX contains methionine sulfoxide (higher molecular mass, 813.92), while SELANK contains native methionine (751.83). Their research focuses also differ: SELANK. is primarily associated with anxiolytic effects, while SEMAX. is associated with nootropic and  neurotrophic effects.

How should the lyophilized powder be stored?

Store at -20°C or below, protected from light and moisture. The native methionine residue can oxidize over time; minimize air exposure and store desiccated.

What solvent should be used for reconstitution?

SELANK is water‑soluble. Common options include sterile water for injection, bacteriostatic water, or buffered solutions such as PBS at neutral pH.

What research applications is SELANK used for?

SELANK is studied in anxiety and stress research, serotonergic and dopaminergic systems, neuropeptide stability, and structure‑activity relationship (SAR) analysis in laboratory cell culture and research models.

Can SELANK be used in combination with other research peptides?

Researchers should determine compatibility based on their specific experimental design. Standard laboratory practice includes testing interactions in control experiments before full‑scale implementation.

Final Notes for Laboratory Researchers

Premium SELANK. represents a high‑purity research tool for qualified professionals conducting legitimate scientific investigations into anxiety mechanisms, stress pathways, serotonin and dopamine systems, and related neuropharmacological fields. With documented third‑party testing, complete chemical specifications, and appropriate packaging for laboratory use, this product meets the standards expected by serious researchers.

The 10mg vial size is optimized for cell culture studies, neurochemical assays, and dose‑response experiments. As a stabilized ACTH(4‑10) analog with native methionine, SELANK offers unique research opportunities for studying the molecular basis of anxiety, stress resilience, and emotional regulation.

For research use only. Not for human or animal consumption. Handle only in appropriate laboratory facilities with proper safety equipment and training.