Premium PT-141 10mg Research Peptide — High-Purity Cyclic Melanocortin Analog for Laboratory Use

PT‑141 10mg

Product Overview

Premium PT‑141 10mg is a research‑grade synthetic cyclic heptapeptide derived from melanotan‑II. It is supplied as a sterile lyophilized powder in sealed vials. Each package contains ten vials, with each vial holding 10mg of the research compound. This product is manufactured exclusively for scientific investigation and in vitro laboratory experimentation.

Key Specifications at a Glance:

• Quantity: 10mg per vial, 10 vials per pack

• Form: Lyophilized (freeze‑dried) powder

• Purity: ≥98% verified by third‑party testing

• Molecular Formula: C₅₀H₆₉N₁₅O₉

• Molecular Mass: 1025.22

• CAS Number: 32780-32-8

• Sequence: Ac‑Nle‑cyclo[Asp‑His‑D‑Phe‑Arg‑Trp‑Lys]‑OH

• Synonyms: Bremelanotide, PT‑141, Melanotan‑II analog

• Research Use Only: Not for human or animal consumption

Understanding PT‑141: The Research Context

PT‑141 is a synthetic cyclic heptapeptide that belongs to the melanocortin family of peptides. It is structurally derived from melanotan‑II, from which it differs by a single amino acid substitution. This modification gives PT‑141 distinct properties that make it valuable for specific research applications, particularly in the study of melanocortin receptor pharmacology. PT‑141 10mg

Key Research Interests:

• Melanocortin receptor (MC1R, MC3R, MC4R) binding and selectivity

• G‑protein coupled receptor (GPCR) signaling pathways

• Cyclic peptide structure‑activity relationships

• In vitro cell culture and receptor pharmacology

Researchers utilize PT‑141 in controlled laboratory settings to better understand melanocortin receptor biology and the molecular mechanisms underlying receptor activation. The peptide is of particular interest to investigators focused on neuroendocrinology, receptor pharmacology, and GPCR signaling.

The Significance of the Melanocortin System:
The melanocortin system consists of five known G‑protein coupled receptors (MC1R through MC5R) that are activated by melanocortin peptides derived from proopiomelanocortin (POMC). These receptors are distributed throughout the body and are involved in diverse physiological functions, including pigmentation, energy homeostasis, and autonomic regulation. PT‑141 is a synthetic agonist that interacts with specific melanocortin receptor subtypes, making it a valuable research tool for studying this receptor family. PT‑141 10mg

PT‑141 vs. Melanotan‑II: A Research Comparison

Researchers often compare PT‑141 with melanotan‑II, as PT‑141 is structurally derived from melanotan‑II.

Choosing Between PT‑141 and Melanotan‑II:
Researchers should select the appropriate peptide based on their specific experimental design and research questions. Both peptides interact with melanocortin receptors but may have different binding affinities and selectivity profiles. Investigators should consult relevant peer‑reviewed literature to determine which compound is most appropriate for their particular research application.

Third‑Party Testing and Quality Assurance

Every batch of Premium PT‑141 undergoes rigorous independent analytical testing to verify identity, purity, and consistency. This third‑party testing ensures that researchers receive a product that meets strict quality specifications before it is approved for release. PT‑141 10mg

The testing process includes:

• Identity verification through mass spectrometry

• Purity analysis using high‑performance liquid chromatography (HPLC)

• Batch‑to‑batch consistency checks

• Residual solvent analysis to confirm complete lyophilization

With a verified purity of ≥98% as confirmed by HPLC, PT‑141 meets the high standards required for serious laboratory research applications. Each vial contains only the lyophilized research compound with no unnecessary additives, fillers, or excipients. Batch‑specific Certificates of Analysis (CoA) are available upon request. PT‑141 10mg

Chemical and Physical Properties

Molecular Characteristics

PT‑141 is a synthetic cyclic heptapeptide with a unique structure that includes a lactam bridge cyclizing the molecule.

Detailed Molecular Information:

• Molecular Formula: C₅₀H₆₉N₁₅O₉

• Molecular Mass: 1025.22 daltons

• CAS Number: 32780-32-8

• Sequence: Ac‑Nle‑cyclo[Asp‑His‑D‑Phe‑Arg‑Trp‑Lys]‑OH

• Purity: ≥98% (HPLC)

• Appearance: White to off‑white lyophilized powder

Structural Features:

• Cyclic heptapeptide (7 amino acids)

• Contains D‑Phe (D‑phenylalanine) instead of L‑Phe

• Acetylated N‑terminus

• Lactam bridge between Asp and Lys residues

• Water‑soluble

The presence of D‑Phe (the D‑isomer of phenylalanine) is a notable structural feature. Most naturally occurring peptides contain only L‑amino acids, so the inclusion of a D‑amino acid makes PT‑141 a non‑natural synthetic peptide with unique properties, including enhanced resistance to proteolytic degradation.

Physical Form and Storage

The product is supplied as a lyophilized (freeze‑dried) powder within a sterile, sealed vial. Lyophilization preserves the chemical integrity of the peptide by removing water content while maintaining the compound’s structure.

Recommended Storage Conditions:

• Store lyophilized powder at -20°C (-4°F) or below for long‑term preservation

• Protect from light exposure

• Keep desiccated to prevent moisture absorption

• Allow vial to reach room temperature before opening to avoid condensation

• Avoid repeated freeze‑thaw cycles once reconstituted

Stability Considerations:
PT‑141 is generally stable when stored properly in lyophilized form. The cyclic structure provides additional stability compared to linear peptides, as the lactam bridge reduces conformational flexibility and may protect against certain degradation pathways.

Once reconstituted with an appropriate sterile solvent, the solution should be used promptly according to laboratory protocols. PT‑141 10mg

Intended Use and Regulatory Status

Research Use Only

PT‑141 is classified as a research chemical and is intended exclusively for laboratory and in vitro experimentation. This designation means the product is sold strictly for:

• In vitro testing — experiments conducted in controlled laboratory environments

• Cell culture studies — investigating peptide interactions with cellular systems

• Receptor binding assays — studying melanocortin receptor interactions

• Signal transduction research — examining GPCR signaling pathways

• Analytical research — chemical analysis and characterization studies

• Scientific investigation — basic research into peptide structure and function

Important Regulatory Notice

This product is not a drug, food, cosmetic, or medical device. Bodily introduction of any kind into humans or animals is strictly forbidden by law. The product should only be handled by licensed, qualified professionals working in appropriate laboratory facilities. PT‑141 10mg

The supplier is a chemical supplier, not a compounding pharmacy or outsourcing facility under Sections 503A or 503B of the Federal Food, Drug, and Cosmetic Act. All product information provided is for educational and research purposes only and does not constitute medical advice or clinical recommendations. PT‑141 10mg

Handling and Safety Guidelines

Professional Handling Required

PT‑141 should only be handled by trained laboratory personnel wearing appropriate personal protective equipment (PPE), including:

• Laboratory coat

• Nitrile gloves

• Safety goggles or face shield

• Appropriate respiratory protection if aerosolization is possible

Reconstitution Protocol

For laboratory use, the lyophilized powder should be reconstituted with a sterile, compatible solvent. Standard practice includes:

1. Allow the sealed vial to reach room temperature — approximately 15-30 minutes

2. Clean the rubber stopper with an alcohol swab

3. Add the calculated volume of solvent to achieve desired concentration

4. Gently swirl or roll the vial between palms — do not shake vigorously to avoid foaming

5. Allow complete dissolution before use — this typically takes 2-5 minutes

Reconstitution Example for PT‑141 10MG:
For researchers needing a 5mg/mL working solution, add 2mL of sterile solvent to the 10mg vial. For a 10mg/mL solution, add 1mL of solvent. For a 2mg/mL solution, add 5mL of solvent. Always verify calculations before proceeding with experiments.

Solvent Considerations:
PT‑141 is water‑soluble. Researchers should determine the appropriate solvent based on their specific experimental protocol. Common options include sterile water for injection, bacteriostatic water, or buffered solutions such as phosphate‑buffered saline (PBS) at neutral pH. PT‑141 10mg

Disposal Considerations

Dispose of PT‑141 10mg and any contaminated materials in accordance with federal, state, and local regulations for chemical waste disposal. Do not dispose of in regular trash or down drains unless permitted by local guidelines. PT‑141 10mg

Research Applications

PT‑141 is used in various laboratory research contexts, primarily focused on melanocortin receptor pharmacology and GPCR signaling. Typical applications include:

Melanocortin Receptor Binding Studies:
The primary research interest in PT‑141 revolves around its interaction with melanocortin receptors. Researchers use PT‑141 10mg to study:

• Receptor binding affinity and kinetics across MC1R‑MC5R subtypes

• Competitive binding assays with endogenous melanocortin ligands

• Structure‑activity relationships (SAR) of cyclic melanocortin agonists

• Receptor binding domain mapping

G‑Protein Coupled Receptor (GPCR) Research:
Melanocortin receptors are members of the GPCR superfamily. PT‑141 serves as a research tool for:

• GPCR activation mechanisms and conformational changes

• Second messenger signaling pathways (cAMP, IP3, calcium)

• Receptor internalization and desensitization studies

• β‑arrestin recruitment assays

Signal Transduction Investigations:
Researchers use PT‑141 10mg to study downstream signaling events following melanocortin receptor activation, including:

• Adenylyl cyclase activation and cAMP production

• Protein kinase A (PKA) signaling

• Mitogen‑activated protein kinase (MAPK) pathways

• Transcriptional regulation downstream of receptor activation

Receptor Selectivity Studies:
Because different melanocortin receptor subtypes have distinct tissue distributions and physiological roles, understanding receptor selectivity is an important research goal. PT‑141 is used to:

• Determine relative binding affinities for different MC receptor subtypes

• Map receptor binding domains and critical interaction sites

• Investigate the molecular basis of receptor selectivity

Cell Culture Studies:
PT‑141 is used in controlled cell culture systems to investigate:

• Melanocortin receptor expression and regulation

• Cellular responses to receptor activation

• Receptor‑mediated gene expression changes

• Functional consequences of melanocortin signaling

Structure‑Activity Relationship (SAR) Analysis:
The synthetic nature of PT‑141 10MG allows researchers to study how specific structural features contribute to its biological activity. SAR studies focus on:

• The role of the cyclic structure in receptor binding

• The importance of the D‑Phe residue

• Contributions of individual amino acids to activity

• Modifications that alter receptor selectivity

Researchers should design their experimental protocols based on peer‑reviewed literature and established laboratory practices specific to melanocortin peptides.

What Makes This Product Different

Unique Cyclic Heptapeptide Structure

Unlike many linear research peptides, PT‑141 has a cyclic structure stabilized by a lactam bridge between aspartic acid and lysine residues. This cyclic conformation provides greater structural rigidity and stability compared to linear peptides, making it a valuable research tool for studying constrained peptide conformations. PT‑141 10mg

D‑Amino Acid Incorporation

The presence of D‑Phe (the D‑isomer of phenylalanine) distinguishes PT‑141 10mg from naturally occurring peptides, which typically contain only L‑amino acids. This feature makes PT‑141 10mg useful for studying the effects of stereochemistry on receptor binding and activity.

Rigorous Quality Control

Unlike research chemicals sold without verification, PT‑141 comes with documented third‑party testing for every batch, including HPLC purity analysis and mass spectrometry identity confirmation.

Batch Traceability

Each package of PT‑141 includes batch identification numbers that allow researchers to trace their material back to original manufacturing and testing records. This traceability is essential for reproducible research and quality documentation. PT‑141 10mg

Frequently Asked Questions for Researchers

What is the purity level of PT‑141 10mg?

Each batch is tested to verify purity of ≥98% via HPLC, with identity confirmed by mass spectrometry. Individual certificates of analysis are available upon request.

What is the significance of the CAS number 32780-32-8?

The CAS number is a unique identifier for PT‑141, allowing researchers to verify they are working with the correct chemical compound when ordering or referencing the peptide in publications.

What is the amino acid sequence of PT‑141?

The sequence is Ac‑Nle‑cyclo[Asp‑His‑D‑Phe‑Arg‑Trp‑Lys]‑OH, where Nle represents norleucine and D‑Phe represents D‑phenylalanine.

How does PT‑141 differ from melanotan‑II?

PT‑141 10mg differs from melanotan‑II by a single amino acid substitution. While both are cyclic heptapeptides, PT‑141 contains a specific modification that alters receptor selectivity and binding profile. PT‑141 10mg

How should the lyophilized powder be stored?

Store at -20°C or below, protected from light and moisture. The cyclic structure provides good stability, but standard peptide storage precautions apply. PT‑141 10mg

What solvent should be used for reconstitution?

PT‑141 10MG is water‑soluble. Common options include sterile water for injection, bacteriostatic water, or buffered solutions such as PBS at neutral pH.

What research applications is PT‑141 10MG used for?

PT‑141 10MG is studied in melanocortin receptor binding, GPCR signaling, receptor selectivity, and structure‑activity relationship (SAR) analysis in laboratory cell culture and research models.

Can PT‑141 10MG be used in combination with other research peptides?

Researchers should determine compatibility based on their specific experimental design. Standard laboratory practice includes testing interactions in control experiments before full‑scale implementation.

Final Notes for Laboratory Researchers

Premium PT‑141 10mg represents a high‑purity research tool for qualified professionals conducting legitimate scientific investigations into melanocortin receptor biology, GPCR signaling, and related pharmacological fields. With documented third‑party testing, complete chemical specifications, and appropriate packaging for laboratory use, this product meets the standards expected by serious researchers.

The 10mg vial size is optimized for receptor binding assays, cell culture studies, and dose‑response experiments. As a cyclic peptide with D‑amino acid content, PT‑141 10MG offers unique research opportunities for studying constrained peptide conformations and stereochemical effects on melanocortin receptor binding.

For research use only. Not for human or animal consumption. Handle only in appropriate laboratory facilities with proper safety equipment and training.