Premium TIRZ 10MG Research Peptide — High-Purity Dual GIP/GLP-1 Receptor Agonist for Laboratory Use

Product Overview

Premium TIRZ (Tirzepatide) 10MG is a research-grade synthetic peptide and a dual agonist of the glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptors. It is supplied as a sterile lyophilized powder in sealed 3mL vials. Each package contains ten vials, with each vial holding 10mg of the research compound. This product is manufactured exclusively for scientific investigation and in vitro laboratory experimentation.

Key Specifications at a Glance:

• Quantity: 10mg per vial, 10 vials per pack

• Form: Lyophilized (freeze-dried) powder

• Vial Volume: 3 mL

• Purity: ≥98% verified by third-party testing

• Molecular Formula: C₂₂₅H₃₄₈N₄₈O₆₈

• Molecular Mass: 4813.45

• CAS Number: 2023788-19-2

• PubChem CID: 156588324

• Research Use Only: Not for human or animal consumption

Understanding TIRZ 10MG: The Research Context

TIRZ is a synthetic research peptide that functions as a dual agonist for the GIP and GLP-1 receptors. Its mechanism of action is characterized by the simultaneous activation of both the GIP and GLP-1 pathways, which are key regulators of metabolic function. This dual agonism distinguishes TIRZ from single-receptor agonists and makes it one of the most advanced peptides currently studied in metabolic research.

Key Research Interests:

• GIP and GLP-1 receptor co-activation and signaling crosstalk

• Insulin secretion and glucose homeostasis

• Food intake regulation and energy balance

• Multifactorial metabolic pathway analysis

• In vitro cell culture investigations

Researchers utilize TIRZ 10MG in controlled laboratory settings to study the integrated biology of the two primary incretin pathways. The peptide is of particular interest to investigators focused on metabolic disorders, appetite regulation, and the fundamental mechanisms of dual incretin receptor pharmacology.

The Significance of Dual Incretin Receptor Agonism:
GLP-1 and GIP are incretin hormones secreted by the gut in response to food intake. Both play complementary roles in metabolism:

• GLP-1: Stimulates glucose-dependent insulin secretion, suppresses glucagon release, slows gastric emptying, and promotes satiety.

• GIP: Enhances insulin secretion and influences lipid metabolism in adipose tissue.

By simultaneously targeting these two key pathways, TIRZ offers a more integrated model for studying metabolic regulation than single-pathway agonists alone.

TIRZ 10MG vs. 30MG: Choosing the Right Quantity for Your Research

Researchers often ask which vial size best suits their laboratory protocols. TIRZ is available in both 10mg and 30mg vial sizes, allowing flexibility based on experimental scale.

Choosing the Right Vial Size:

• TIRZ 10MG — Ideal for preliminary pilot studies, initial dose‑finding experiments, and research requiring precise handling of smaller quantities. It allows researchers to test hypotheses without committing to larger amounts.

• TIRZ 30MG — Suitable for large‑scale experiments, extended time‑course studies, multiple replicated assays, and protocols requiring consistent batch material across many samples.

Both sizes share identical chemical properties, purity standards (≥98%), and quality assurance protocols. The choice depends on the specific requirements of your research design.

Third-Party Testing and Quality Assurance

Every batch of TIRZ 10MG undergoes rigorous independent analytical testing to verify identity, purity, and consistency. This third-party testing ensures that researchers receive a product that meets strict quality specifications before it is approved for release.

The testing process includes:

• Identity verification through mass spectrometry

• Purity analysis using high-performance liquid chromatography (HPLC)

• Batch-to-batch consistency checks

• Residual solvent analysis to confirm complete lyophilization

With a verified purity of ≥98% as confirmed by HPLC, TIRZ 10MG meets the high standards required for serious laboratory research applications. Each vial contains only the lyophilized research compound with no unnecessary additives, fillers, or excipients. Batch‑specific Certificates of Analysis (CoA) are available upon request.

Chemical and Physical Properties

Molecular Characteristics

TIRZ is a synthetic 39-amino acid peptide engineered for dual GIP and GLP-1 receptor agonism. Its specific sequence modifications enable high-affinity binding to both receptors.

Detailed Molecular Information:

• Molecular Formula: C₂₂₅H₃₄₈N₄₈O₆₈

• Molecular Mass: 4813.45 daltons

• CAS Number: 2023788-19-2

• Purity: ≥98% (HPLC)

• Appearance: White to off‑white lyophilized powder

Structural Features:

• Synthetic 39-amino acid peptide

• Features a C-terminal amide

• Contains non-coded amino acids

• Displays balanced dual incretin receptor activity

Physical Form and Storage

The product is supplied as a lyophilized (freeze-dried) powder within a sterile, sealed 3mL vial. Lyophilization preserves the chemical integrity of the peptide by removing water content while maintaining the compound’s structure.

Recommended Storage Conditions:

• Store lyophilized powder at -20°C (-4°F) or below for long-term preservation

• Protect from light exposure

• Keep desiccated to prevent moisture absorption

• Allow vial to reach room temperature before opening to avoid condensation

• Avoid repeated freeze-thaw cycles once reconstituted

Stability Considerations:
Short-term storage (weeks) can be maintained at 0-4°C in a dry environment. For extended preservation, -20°C storage under dry conditions is recommended. Lyophilized products stored at -20°C have a shelf life of up to three years.

Once reconstituted with an appropriate sterile solvent, the solution should be used promptly according to laboratory protocols.

Intended Use and Regulatory Status

Research Use Only

TIRZ 10MG is classified as a research chemical and is intended exclusively for laboratory and in vitro experimentation. This designation means the product is sold strictly for:

• In vitro testing — experiments conducted in controlled laboratory environments

• Cell culture studies — investigating GIP and GLP-1 receptor signaling

• Receptor binding assays — studying dual GIPR and GLP-1R interactions

• Metabolic research — investigating glucose homeostasis and energy balance

• Analytical research — chemical analysis and characterization studies

• Scientific investigation — basic research into incretin hormone structure and function

Important Regulatory Notice

This product is not a drug, food, cosmetic, or medical device. Bodily introduction of any kind into humans or animals is strictly forbidden by law. The product should only be handled by licensed, qualified professionals working in appropriate laboratory facilities.

The supplier is a chemical supplier, not a compounding pharmacy or outsourcing facility under Sections 503A or 503B of the Federal Food, Drug, and Cosmetic Act. All product information provided is for educational and research purposes only and does not constitute medical advice or clinical recommendations.

Handling and Safety Guidelines

Professional Handling Required

TIRZ 10MG should only be handled by trained laboratory personnel wearing appropriate personal protective equipment (PPE), including:

• Laboratory coat

• Nitrile gloves

• Safety goggles or face shield

• Appropriate respiratory protection if aerosolization is possible

Reconstitution Protocol

For laboratory use, the lyophilized powder should be reconstituted with a sterile, compatible solvent. Standard practice includes:

1. Allow the sealed vial to reach room temperature — approximately 15-30 minutes

2. Clean the rubber stopper with an alcohol swab

3. Add the calculated volume of solvent to achieve desired concentration

4. Gently swirl or roll the vial between palms — do not shake vigorously to avoid foaming

5. Allow complete dissolution before use — this typically takes 2-5 minutes

Reconstitution Example for TIRZ 10MG:
For researchers needing a 10mg/mL working solution, add 1mL of sterile solvent to the 10mg vial. For a 5mg/mL solution, add 2mL of solvent. For a 2mg/mL solution, add 5mL of solvent. Always verify calculations before proceeding with experiments.

Solvent Considerations:
Researchers should determine the appropriate solvent based on their specific experimental protocol. Common options include sterile water for injection, bacteriostatic water, or buffered solutions such as phosphate-buffered saline (PBS) at neutral pH.

Disposal Considerations

Dispose of TIRZ 10MG and any contaminated materials in accordance with federal, state, and local regulations for chemical waste disposal. Do not dispose of in regular trash or down drains unless permitted by local guidelines.

Research Applications

TIRZ 10MG is used in various laboratory research contexts, primarily focused on the integrated biology of GIP and GLP-1 receptor signaling. Typical applications include:

Dual GIP and GLP-1 Receptor Signaling Studies:
The primary research interest in TIRZ revolves around its simultaneous activation of two distinct GPCR pathways. Researchers use TIRZ to study:

• GIPR and GLP-1R co-activation and crosstalk mechanisms

• Receptor binding affinity and kinetics

• Gs protein coupling and cAMP signaling integration

• Receptor-specific effects on insulin secretion and gene transcription

Metabolic Pathway Research:
TIRZ’s dual agonist profile allows researchers to investigate integrated metabolic signaling:

• Glucose-dependent insulin secretion pathways

• Energy homeostasis and satiety signaling

• Adipose tissue lipid metabolism

• Gastric emptying and gastrointestinal motility

Cell Culture Investigations:
Researchers use TIRZ in controlled cell culture systems to study:

• Pancreatic beta-cell function and proliferation

• Adipocyte differentiation and lipid storage

• Enteroendocrine cell hormone secretion

• Signaling pathway integration in target cells

Comparative Receptor Pharmacology:
The dual agonist nature of TIRZ makes it valuable for:

• Comparing mono-agonist vs. dual-agonist signaling profiles

• Investigating the functional significance of GIPR vs. GLP-1R activation

• Studying synergistic effects on metabolic endpoints

GPCR Signaling Research:
Both GIPR and GLP-1R are class B GPCRs. TIRZ serves as a research tool for:

• G protein coupling and specificity

• Beta-arrestin recruitment and receptor trafficking

• Receptor internalization and desensitization kinetics

Researchers should design their experimental protocols based on peer-reviewed literature and established laboratory practices specific to incretin receptor agonists.

What Makes This Product Different

Dual GIP and GLP-1 Receptor Agonist

Unlike single-receptor agonists that target only GLP-1R, TIRZ activates both the GIP and GLP-1 receptors simultaneously. This dual-agonist mechanism allows researchers to study the integrated effects of both incretin pathways in a single experimental model.

High-Performance Liquid Chromatography (HPLC) Testing

TIRZ 10MG is analyzed using HPLC to confirm purity of ≥98%. Each batch is also verified by mass spectrometry to ensure correct peptide identity, and batch-specific Certificates of Analysis (CoA) are available upon request.

Optimal 10MG Research Quantity for Smaller-Scale Studies

The 10mg vial size is ideal for:

• Preliminary and pilot studies requiring smaller quantities

• Dose-finding experiments across multiple concentrations

• Precise handling for low-concentration protocols

• Cost-effective initial investigations before scaling up

Batch Traceability

Each package of TIRZ 10MG includes batch identification numbers that allow researchers to trace their material back to original manufacturing and testing records. This traceability is essential for reproducible research and quality documentation. TIRZ 10MG

Frequently Asked Questions for Researchers

What is the purity level of TIRZ 10MG?

Each batch is tested to verify purity of ≥98% via HPLC, with identity confirmed by mass spectrometry. Individual certificates of analysis are available upon request.

What is the difference between TIRZ 10MG and 30MG?

The only difference is the quantity per vial. TIRZ 10MG contains 10mg per vial, while TIRZ 30MG contains 30mg per vial. Both share identical chemical properties, purity standards (≥98%), and quality assurance protocols. TIRZ 10MG

Which vial size should I choose for my research?

Choose 10MG for smaller-scale experiments, pilot studies, dose-finding protocols, or when precise handling of smaller quantities is required. Choose 30MG for larger-scale studies, replicated assays, or established protocols requiring consistent batch material across many experiments.

How should the lyophilized powder be stored?

Store at -20°C or below for long-term preservation, protected from light and moisture. Short-term storage (weeks) can be at 0-4°C in a dry environment. Avoid repeated freeze-thaw cycles once reconstituted. TIRZ 10MG

What solvent should be used for reconstitution?

Researchers should determine the appropriate solvent based on their specific experimental protocol. Common options include sterile water for injection, bacteriostatic water, or buffered solutions such as PBS at neutral pH. TIRZ 10MG

Is this product sterile?

The lyophilized powder is manufactured under aseptic conditions, but researchers should follow standard laboratory practices for handling research chemicals. For cell culture applications, additional filtration using a 0.22-micron filter may be appropriate.

What is the mechanism of action of TIRZ?

TIRZ is a dual agonist of the GIP and GLP-1 receptors. It activates both receptors, leading to increased glucose-dependent insulin secretion, improved glucose homeostasis, and modulation of energy balance pathways.

What research applications is TIRZ used for?

TIRZ is studied in GIP/GLP-1 receptor co-activation research, metabolic regulation, insulin secretion studies, receptor pharmacology, and metabolic pathway investigations in laboratory cell culture and research models. TIRZ 10MG

Can TIRZ be used in combination with other research peptides?

Researchers should determine compatibility based on their specific experimental design. Standard laboratory practice includes testing interactions in control experiments before full-scale implementation.

Final Notes for Laboratory Researchers

Premium TIRZ 10MG represents a high-purity research tool for qualified professionals conducting legitimate scientific investigations into dual incretin receptor signaling, metabolic regulation, and related fields. With documented third-party testing, complete chemical specifications, and appropriate packaging for laboratory use, this product meets the standards expected by serious researchers.

The 10mg vial size is specifically optimized for smaller-scale experiments, preliminary studies, dose-finding protocols, and research requiring precise handling of smaller quantities. For larger-scale research requiring more material per vial, TIRZ 30MG is also available. As a dual agonist of GIP and GLP-1 receptors, TIRZ offers unique research opportunities for studying the integrated biology of the two primary incretin pathways.

For research use only. Not for human or animal consumption. Handle only in appropriate laboratory facilities with proper safety equipment and training.