MOTS-C 10 MG

Premium MOTS-C 10MG Research Peptide — Mitochondrial‑Derived Peptide for Laboratory Use

Product Overview

Premium MOTS‑C is a research‑grade mitochondrial‑derived peptide (MDP) encoded within the mitochondrial genome. It is supplied as a sterile lyophilized powder in sealed vials. Each package contains ten vials, with each vial holding 10mg of the research compound. This product is manufactured exclusively for scientific investigation and in vitro laboratory experimentation.

Key Specifications at a Glance:

• Quantity: 10mg per vial, 10 vials per pack

• Form: Lyophilized (freeze‑dried) powder

• Purity: ≥99% verified by third‑party testing

• Molecular Formula: C₉₇H₁₅₀N₂₈O₂₇

• Molecular Mass: 2174.53

• CAS Number: 1627580-64-6

• Sequence: MRWQEMGYIFYPRKLR (H-Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg-OH)

• Research Use Only: Not for human or animal consumption

Understanding MOTS‑C: The Research Context

MOTS‑C is a synthetic research peptide that corresponds to a naturally occurring mitochondrial‑derived peptide encoded within the mitochondrial genome. Unlike most peptides that are encoded by nuclear DNA, MOTS‑C is one of a growing class of peptides encoded by short open reading frames (sORFs) within mitochondrial DNA (mtDNA). MOTS-C 10 MG

Key Research Interests:

• AMPK pathway activation and metabolic regulation

• Glucose metabolism and insulin sensitivity

• Mitochondrial biology and intercellular communication

• Cellular energy homeostasis

• In vitro cell culture investigations

Researchers utilize MOTS‑C in controlled laboratory settings to study the emerging field of mitochondrial‑derived peptides and their roles in cellular metabolism. The peptide is of particular interest to investigators focused on metabolic disorders, mitochondrial dysfunction, and the fundamental mechanisms of intercellular signaling. MOTS-C 10 MG

The Significance of Mitochondrial‑Derived Peptides:
Mitochondria are organelles traditionally known for energy production, but research has revealed that they also produce signaling molecules, including a family of peptides encoded within mitochondrial DNA. MOTS‑C is a 16‑amino acid peptide that has been the subject of research into its potential roles in:

• Metabolic regulation through AMPK activation

• Cellular stress responses

• Inter‑tissue communication

• Systemic metabolic homeostasis

This emerging class of signaling molecules represents a relatively new area of biological investigation, and MOTS‑C serves as a valuable research tool for exploring mitochondrial‑nuclear communication pathways. MOTS-C 10 MG

The MOTS‑C Amino Acid Sequence

MOTS‑C is a 16‑amino acid peptide with the following sequence:

Full Sequence: H-Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg-OH

Abbreviated Sequence: MRWQEMGYIFYPRKLR

Key Sequence Features:

• Contains multiple aromatic amino acids (tryptophan, tyrosine, phenylalanine)

• Includes positively charged residues (arginine, lysine)

• Contains two methionine residues

• Length of 16 amino acids

The presence of multiple aromatic and positively charged residues contributes to the peptide’s structural properties and potential interaction with cellular targets.

Third‑Party Testing and Quality Assurance

Every batch of Premium MOTS‑C 10MG undergoes rigorous independent analytical testing to verify identity, purity, and consistency. This third‑party testing ensures that researchers receive a product that meets strict quality specifications before it is approved for release. MOTS-C 10 MG

The testing process includes:

• Identity verification through mass spectrometry

• Purity analysis using high‑performance liquid chromatography (HPLC)

• Batch‑to‑batch consistency checks

• Residual solvent analysis to confirm complete lyophilization

With a verified purity of ≥99% as confirmed by HPLC, MOTS‑C meets the high standards required for serious laboratory research applications. Each vial contains only the lyophilized research compound with no unnecessary additives, fillers, or excipients. Batch‑specific Certificates of Analysis (CoA) are available upon request. MOTS-C 10 MG

Chemical and Physical Properties

Molecular Characteristics

MOTS‑C is a synthetic 16‑amino acid peptide with a molecular mass of 2174.53 daltons.

Detailed Molecular Information:

• Molecular Formula: C₉₇H₁₅₀N₂₈O₂₇

• Molecular Mass: 2174.53 g/mol

• CAS Number: 1627580-64-6

• Sequence: MRWQEMGYIFYPRKLR

• Number of Amino Acids: 16

• Purity: ≥99% (HPLC)

• Appearance: White to off‑white lyophilized powder

Structural Features:

• Linear peptide (non‑cyclic)

• Contains two methionine residues (susceptible to oxidation)

• Multiple aromatic residues (Trp, Tyr, Phe)

• Positively charged residues at positions 2, 13, 14, and 16

Physical Form and Storage

The product is supplied as a lyophilized (freeze‑dried) powder within a sterile, sealed vial. Lyophilization preserves the chemical integrity of the peptide by removing water content while maintaining the compound’s structure. MOTS-C 10 MG

Recommended Storage Conditions:

• Store lyophilized powder at -20°C (-4°F) or below for long‑term preservation

• Protect from light exposure

• Keep desiccated to prevent moisture absorption

• Allow vial to reach room temperature before opening to avoid condensation

• Avoid repeated freeze‑thaw cycles once reconstituted

Stability Considerations:
MOTS‑C contains methionine residues, which can be susceptible to oxidation. For this reason, minimizing air exposure and avoiding repeated opening of stock vials is particularly important. Consider aliquoting reconstituted material if extended storage is required. Lyophilized powder stored at -20°C is stable for up to 24 months. MOTS-C 10 MG

Once reconstituted with an appropriate sterile solvent, the solution should be used promptly according to laboratory protocols. MOTS-C 10 MG

Intended Use and Regulatory Status

Research Use Only

MOTS‑C is classified as a research chemical and is intended exclusively for laboratory and in vitro experimentation. This designation means the product is sold strictly for:

• In vitro testing — experiments conducted in controlled laboratory environments

• Cell culture studies — investigating mitochondrial peptide signaling

• Metabolic research — studying glucose and energy metabolism

• Mitochondrial biology — exploring mitochondrial‑nuclear communication

• Analytical research — chemical analysis and characterization studies

• Scientific investigation — basic research into mitochondrial‑derived peptides

Important Regulatory Notice

This product is not a drug, food, cosmetic, or medical device. Bodily introduction of any kind into humans or animals is strictly forbidden by law. The product should only be handled by licensed, qualified professionals working in appropriate laboratory facilities.

The supplier is a chemical supplier, not a compounding pharmacy or outsourcing facility under Sections 503A or 503B of the Federal Food, Drug, and Cosmetic Act. All product information provided is for educational and research purposes only and does not constitute medical advice or clinical recommendations. MOTS-C 10 MG

Handling and Safety Guidelines

Professional Handling Required

MOTS‑C should only be handled by trained laboratory personnel wearing appropriate personal protective equipment (PPE), including:

• Laboratory coat

• Nitrile gloves

• Safety goggles or face shield

• Appropriate respiratory protection if aerosolization is possible

Reconstitution Protocol

For laboratory use, the lyophilized powder should be reconstituted with a sterile, compatible solvent. Standard practice includes:

1. Allow the sealed vial to reach room temperature — approximately 15-30 minutes

2. Clean the rubber stopper with an alcohol swab

3. Add the calculated volume of solvent to achieve desired concentration

4. Gently swirl or roll the vial between palms — do not shake vigorously to avoid foaming

5. Allow complete dissolution before use — this typically takes 2-5 minutes

Reconstitution Example for MOTS‑C 10MG:
For researchers needing a 5mg/mL working solution, add 2mL of sterile solvent to the 10mg vial. For a 10mg/mL solution, add 1mL of solvent. For a 2mg/mL solution, add 5mL of solvent. Always verify calculations before proceeding with experiments.

Solvent Considerations:
MOTS‑C is soluble in DMSO at ≥1 mg/mL for stock solutions. For aqueous applications, test solubility in your specific buffer system. Researchers may also use sterile water for injection or buffered solutions such as PBS at neutral pH.

Disposal Considerations

Dispose of MOTS‑C and any contaminated materials in accordance with federal, state, and local regulations for chemical waste disposal. Do not dispose of in regular trash or down drains unless permitted by local guidelines. MOTS-C 10 MG

Research Applications

MOTS‑C is used in various laboratory research contexts, primarily focused on mitochondrial biology and metabolic regulation. Typical applications include:

AMPK Pathway and Metabolic Research:
The primary research interest in MOTS‑C revolves around its activation of the AMPK pathway. Researchers use MOTS‑C to study:

• AMPK activation mechanisms and downstream signaling

• Glucose uptake and insulin sensitivity in cell culture models

• Prevention of high‑fat diet‑induced metabolic changes

• GLUT4 expression and translocation

Mitochondrial Biology Research:
As a mitochondrial‑derived peptide, MOTS‑C is used to study:

• Mitochondrial genome‑encoded signaling molecules

• Intercellular communication mediated by mitochondrial peptides

• Cellular stress responses involving mitochondrial signaling

• Mitochondrial‑nuclear communication pathways

Metabolic Studies:
MOTS‑C has been the subject of research into metabolic regulation, including:

• Glucose metabolism and insulin signaling

• Cellular energy homeostasis

• Metabolic pathway regulation

• Substrate utilization in cell culture systems

Cell Culture Investigations:
Researchers use MOTS‑C in controlled cell culture systems to study:

• Cellular responses to mitochondrial peptide signaling

• Gene expression changes following peptide treatment

• Metabolic flux and energy balance

• Cell viability and proliferation under various conditions

Aging Research:
Mitochondrial function declines with age, and mitochondrial‑derived peptides are being studied in the context of:

• Age‑related metabolic changes

• Cellular senescence

• Mitochondrial dysfunction in aging models

• Longevity pathways

Researchers should design their experimental protocols based on peer‑reviewed literature and established laboratory practices specific to mitochondrial‑derived peptides.

What Makes This Product Different

Mitochondrial Genome Origin

Unlike the vast majority of research peptides that are encoded by nuclear DNA, MOTS‑C is encoded within the mitochondrial genome. This unique origin makes MOTS‑C a valuable research tool for investigators studying mitochondrial biology and the emerging field of mitochondrial‑derived signaling molecules. MOTS-C 10 MG

AMPK Pathway Activation

MOTS‑C is a well‑characterized activator of the AMPK pathway, a central regulator of cellular energy homeostasis. This specific mechanism of action distinguishes MOTS‑C from peptides that target other signaling pathways. MOTS-C 10 MG

Optimal 10MG Research Quantity

The 10mg vial size is ideal for:

• Moderate‑scale studies requiring consistent batch material

• Standard cell culture experiments

• Multiple experiments without vial‑to‑vial variation

• Cost‑effective quantity for established research protocols

Rigorous Quality Control

Unlike research chemicals sold without verification, MOTS‑C comes with documented third‑party testing for every batch, including HPLC purity analysis and mass spectrometry identity confirmation.

Batch Traceability

Each package of MOTS‑C includes batch identification numbers that allow researchers to trace their material back to original manufacturing and testing records. This traceability is essential for reproducible research and quality documentation. MOTS-C 10 MG

Frequently Asked Questions for Researchers

What is the purity level of MOTS‑C?

Each batch is tested to verify purity of ≥99% via HPLC, with identity confirmed by mass spectrometry. Individual certificates of analysis are available upon request.

What is the significance of the CAS number 1627580-64-6?

The CAS number is a unique identifier for MOTS‑C, allowing researchers to verify they are working with the correct chemical compound when ordering or referencing the peptide in publications.

What is the amino acid sequence of MOTS‑C?

The sequence is MRWQEMGYIFYPRKLR (H-Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg-OH). MOTS-C 10 MG

What does it mean that MOTS‑C is a mitochondrial‑derived peptide?

Unlike most peptides encoded by nuclear DNA, MOTS‑C is encoded by a short open reading frame within mitochondrial DNA. This makes it part of an emerging class of signaling molecules produced by mitochondria.

How should the lyophilized powder be stored?

Store at -20°C or below, protected from light and moisture. Due to the presence of methionine residues, minimizing air exposure is particularly important. Avoid repeated freeze‑thaw cycles once reconstituted.

What solvent should be used for reconstitution?

MOTS‑C is soluble in DMSO at ≥1 mg/mL for stock solutions. For aqueous applications, test solubility in your specific buffer system. Common options include sterile water for injection or PBS at neutral pH. MOTS-C 10 MG

Is this product sterile?

The lyophilized powder is manufactured under aseptic conditions, but researchers should follow standard laboratory practices for handling research chemicals. For cell culture applications, additional filtration using a 0.22‑micron filter may be appropriate. MOTS-C 10 MG

What research applications is MOTS‑C used for?

MOTS‑C is studied in mitochondrial biology, metabolic regulation (AMPK pathway), glucose metabolism, insulin sensitivity, and aging research in laboratory cell culture and research models.

Can MOTS‑C be used in combination with other research peptides?

Researchers should determine compatibility based on their specific experimental design. Standard laboratory practice includes testing interactions in control experiments before full‑scale implementation. MOTS-C 10 MG

Final Notes for Laboratory Researchers

Premium MOTS‑C 10MG represents a high‑purity research tool for qualified professionals conducting legitimate scientific investigations into mitochondrial‑derived peptides, AMPK signaling, metabolic regulation, and related fields. With documented third‑party testing, complete chemical specifications, and appropriate packaging for laboratory use, this product meets the standards expected by serious researchers. MOTS-C 10 MG

The 10mg vial size is specifically optimized for moderate‑scale research applications requiring consistent batch material for standard cell culture studies, metabolic assays, and AMPK pathway investigations. As a peptide encoded by mitochondrial DNA with well‑characterized AMPK‑activating properties, MOTS‑C offers unique research opportunities in the growing fields of mitochondrial signaling and metabolic regulation. MOTS-C 10 MG

For research use only. Not for human or animal consumption. Handle only in appropriate laboratory facilities with proper safety equipment and training. MOTS-C 10 MG