BPC-157

 BPC‑157 Research Peptide — High‑Purity Body Protection Compound for Laboratory Use

Product Overview

BPC‑157 (Body Protection Compound‑157) is a research‑grade synthetic pentadecapeptide derived from a protective gastric protein. It is supplied as a sterile lyophilized powder in sealed vials. Each package contains ten vials, with each vial holding 5 mg of the research compound. This product is manufactured exclusively for scientific investigation and in vitro laboratory experimentation.

Key Specifications at a Glance:

• Quantity: 5 mg per vial, 10 vials per pack

• Form: Lyophilized (freeze‑dried) powder

• Purity: ≥99% verified by third‑party testing

• Molecular Formula: C₆₂H₉₈N₁₆O₂₂

• Molecular Mass: 1419.6 g/mol

• CAS Number: 137525‑51‑0

• Sequence: Gly‑Glu‑Pro‑Pro‑Pro‑Gly‑Lys‑Pro‑Ala‑Asp‑Asp‑Ala‑Gly‑Leu‑Val (GEPPPGKPADDAGLV)

• Synonyms: BPC 157, PL 14736, PL‑10

• Research Use Only: Not for human or animal consumption

Understanding BPC‑157: The Research Context

BPC‑157 is a synthetic pentadecapeptide (15 amino acids) corresponding to a fragment of a naturally occurring gastric protein. It was initially identified through research into gastrointestinal mucosal protection and has since become one of the most extensively studied peptides in regenerative research. BPC-157

Key Research Interests:

• Cytoprotective signaling and tissue protection mechanisms

• Angiogenesis and blood vessel formation

• Nitric oxide pathway modulation

• Tendon, ligament, and muscle healing models

• Gastrointestinal barrier integrity

• In vitro cell culture investigations

Researchers utilize BPC‑157 in controlled laboratory settings to study its role in tissue protection, repair, and regeneration. The peptide is of particular interest to investigators focused on musculoskeletal repair, gastrointestinal health, and the fundamental mechanisms of tissue healing.

The Significance of BPC‑157’s Origin:
BPC‑157 was discovered through research into gastric juice proteins that protect the stomach lining from its own acidic environment. These proteins demonstrate remarkable stability, surviving exposure to extreme acidic conditions (pH 1.5‑3.5). This stability is retained in the synthetic BPC‑157 fragment, making it unusually resilient in laboratory settings compared to many other research peptides. BPC-157

The “Body Protection” Concept:
The peptide’s name reflects its broad cytoprotective properties observed in research. Unlike many peptides that target specific receptors or pathways, BPC‑157 appears to influence multiple aspects of tissue repair, including:

• Promoting blood vessel formation (angiogenesis)

• Modulating nitric oxide signaling

• Protecting cells from various forms of damage

• Supporting tissue organization during healing

BPC‑157 5 mg vs. 10 mg: Choosing the Right Quantity

Researchers often ask which vial size best suits their laboratory protocols. BPC‑157 is available in both 5 mg and 10 mg vial sizes. BPC-157

Choosing the Right Vial Size:

• BPC‑157 5 mg — Ideal for preliminary pilot studies, initial dose‑finding experiments, and research requiring precise handling of smaller quantities per vial.

Both sizes share identical chemical properties, purity standards (≥99%), and quality assurance protocols. BPC-157

Third‑Party Testing and Quality Assurance

Every batch of Premium BPC‑157 undergoes rigorous independent analytical testing to verify identity, purity, and consistency. This third‑party testing ensures that researchers receive a product that meets strict quality specifications before it is approved for release. BPC-157

The testing process includes:

• Identity verification through mass spectrometry

• Purity analysis using high‑performance liquid chromatography (HPLC) — ≥99%

• Batch‑to‑batch consistency checks

• Endotoxin testing (<0.05 EU/mg) for cell culture applications

• Residual solvent analysis to confirm complete lyophilization

With a verified purity of ≥99%, BPC‑157 meets the high standards required for serious laboratory research applications. Each vial contains only the lyophilized research compound with no unnecessary additives, fillers, or excipients. Batch‑specific Certificates of Analysis (CoA) are available upon request. BPC-157

Chemical and Physical Properties

Molecular Characteristics

BPC‑157 is a synthetic 15‑amino acid linear peptide with a specific sequence derived from a gastric protein fragment. BPC-157

Detailed Molecular Information:

• Molecular Formula: C₆₂H₉₈N₁₆O₂₂

• Molecular Mass: 1419.6 g/mol

• CAS Number: 137525‑51‑0

• Sequence: GEPPPGKPADDAGLV (Gly‑Glu‑Pro‑Pro‑Pro‑Gly‑Lys‑Pro‑Ala‑Asp‑Asp‑Ala‑Gly‑Leu‑Val)

• Number of Amino Acids: 15

• Purity: ≥99% (HPLC)

• Appearance: White to off‑white lyophilized powder

Amino Acid Breakdown and Properties:

Structural Features:

• Linear pentadecapeptide (15 amino acids)

• Contains three consecutive prolines (positions 3‑5), creating a structurally rigid region

• Contains multiple negatively charged residues (glutamic acid, aspartic acid)

• Contains positively charged lysine

• Hydrophobic C‑terminus (leucine, valine)

The cluster of three consecutive prolines (Pro‑Pro‑Pro) is a notable structural feature that contributes to the peptide’s stability and biological activity. BPC-157

Physical Form and Storage

The product is supplied as a lyophilized (freeze‑dried) powder within a sterile, sealed vial.

Recommended Storage Conditions:

• Store lyophilized powder at -20°C (-4°F) or below for long‑term preservation (stable for ≥24 months)

• Protect from light exposure

• Keep desiccated to prevent moisture absorption

• Allow vial to reach room temperature before opening to avoid condensation

• Avoid repeated freeze‑thaw cycles once reconstituted

Stability Considerations:
BPC‑157 is remarkably stable due to its gastric protein origin. It remains intact under acidic conditions (pH 1.5‑3.5) and resists proteolytic degradation, making it suitable for extended research protocols. BPC-157

Once reconstituted with an appropriate sterile solvent, the solution should be stored at 2‑8°C and used within 30 days. For longer storage, freeze aliquots at -20°C or -80°C.

Intended Use and Regulatory Status

Research Use Only

BPC‑157 is classified as a research chemical and is intended exclusively for laboratory and in vitro experimentation. This designation means the product is sold strictly for:

• In vitro testing — experiments conducted in controlled laboratory environments

• Cell culture studies — investigating cytoprotective signaling pathways

• Angiogenesis research — studying blood vessel formation mechanisms

• Tissue repair studies — musculoskeletal and soft tissue healing models

• Gastrointestinal research — barrier integrity and mucosal protection

• Analytical research — chemical analysis and characterization

• Scientific investigation — basic research into gastric‑derived peptides

Important Regulatory Notice

This product is not a drug, food, cosmetic, or medical device. Bodily introduction of any kind into humans or animals is strictly forbidden by law. The product should only be handled by licensed, qualified professionals working in appropriate laboratory facilities. BPC-157

The supplier is a chemical supplier, not a compounding pharmacy or outsourcing facility under Sections 503A or 503B of the Federal Food, Drug, and Cosmetic Act. All product information provided is for educational and research purposes only and does not constitute medical advice or clinical recommendations. BPC-157

Handling and Safety Guidelines

Professional Handling Required

BPC‑157 should only be handled by trained laboratory personnel wearing appropriate personal protective equipment (PPE), including:

• Laboratory coat

• Nitrile gloves

• Safety goggles or face shield

• Appropriate respiratory protection if aerosolization is possible

Reconstitution Protocol

For laboratory use, the lyophilized powder should be reconstituted with a sterile, compatible solvent. Standard practice includes:

1. Allow the sealed vial to reach room temperature — approximately 15‑30 minutes

2. Clean the rubber stopper with an alcohol swab

3. Add the calculated volume of solvent to achieve desired concentration

4. Gently swirl or roll the vial between palms — do not shake vigorously to avoid foaming

5. Allow complete dissolution before use — this typically takes 2‑5 minutes

Reconstitution Example for BPC‑157 5 mg:

• For a 5 mg/mL solution: add 1 mL of sterile solvent

• For 2.5 mg/mL: add 2 mL of solvent

• For 1 mg/mL: add 5 mL of solvent

• For 0.5 mg/mL: add 10 mL of solvent

Always verify calculations before proceeding with experiments.

Solvent Considerations:
BPC‑157 is water‑soluble. Common options include sterile water for injection, bacteriostatic water, or buffered solutions such as phosphate‑buffered saline (PBS) at neutral pH.

Disposal Considerations

Dispose of BPC‑157 and any contaminated materials in accordance with federal, state, and local regulations for chemical waste disposal. BPC-157

Research Applications

BPC‑157 is used in various laboratory research contexts, spanning gastrointestinal biology, musculoskeletal repair, and angiogenesis research. BPC-157

Angiogenesis and Vascular Research:
Researchers use BPC‑157 to study:

• Vascular endothelial growth factor (VEGF) expression and activation

• Endothelial cell proliferation and migration

• Capillary formation and vascular density

Tendon, Ligament, and Musculoskeletal Studies:

• Tendon healing and collagen organization

• Ligament repair mechanisms

• Muscle regeneration and recovery

Gastrointestinal Barrier Research:

• Intestinal epithelial barrier integrity

• Mucosal protection mechanisms

• Inflammatory bowel disease models

Cytoprotective Signaling Studies:

• Nitric oxide (NO) signaling modulation

• Pro‑survival pathway activation

• Oxidative stress reduction mechanisms

Cell Culture Investigations:

• Fibroblast proliferation and migration

• Endothelial cell tube formation (angiogenesis assays)

• Epithelial cell barrier function

Researchers should design their experimental protocols based on peer‑reviewed literature.

What Makes This Product Different

Exceptional Stability

BPC‑157 retains the remarkable stability of its gastric protein origin, remaining intact at pH 1.5‑3.5 and resisting proteolytic degradation, making it uniquely suitable for extended research protocols.

Broad Cytoprotective Profile

BPC‑157 influences multiple tissue protection and repair pathways simultaneously, including angiogenesis, nitric oxide signaling, and cell survival pathways. BPC-157

Rigorous Quality Control

Unlike research chemicals sold without verification, BPC‑157 comes with documented third‑party testing for every batch, including HPLC purity analysis, mass spectrometry identity confirmation, and endotoxin testing (<0.05 EU/mg). BPC-157

Batch Traceability

Each package includes batch identification numbers for full traceability, essential for reproducible research. BPC-157

Frequently Asked Questions for Researchers

What is the purity level of BPC‑157? ≥99% via HPLC, identity confirmed by mass spectrometry. CoA available upon request. BPC-157

What is the sequence? GEPPPGKPADDAGLV (15 amino acids).

Why is BPC‑157 unusually stable? It is derived from a gastric protein that naturally survives stomach acid (pH 1.5‑3.5) and digestive enzymes.

How should it be stored? Lyophilized: -20°C, desiccated, protected from light. Reconstituted: 2‑8°C for up to 30 days, or freeze aliquots.

What solvent? Water‑soluble; use sterile water, bacteriostatic water, or PBS (pH 7.0‑7.4).

Can it be combined with other peptides? Yes, frequently studied with GHK‑Cu and TB‑500 in GLOW/KLOW formulations. Test compatibility experimentally.

Final Notes for Laboratory Researchers

Premium BPC‑157 represents a high‑purity research tool for qualified professionals conducting legitimate scientific investigations into cytoprotective signaling, angiogenesis, tissue repair mechanisms, and gastrointestinal barrier function. With documented third‑party testing and complete specifications, this product meets the standards expected by serious researchers.

The 5 mg vial size is optimized for smaller‑scale experiments, pilot studies, and precise dose‑finding. For larger‑scale research, BPC‑157 is also available in 10 mg vials.

For research use only. Not for human or animal consumption. Handle only in appropriate laboratory facilities with proper safety equipment and training.