Premium TESA 10MG Research Peptide — High-Purity GHRH Analog for Laboratory Use

Product Overview

Premium TESA (Tesamorelin) 10MG is a research-grade synthetic analog of growth hormone-releasing hormone (GHRH). It is supplied as a sterile lyophilized powder in sealed vials. Each package contains ten vials, with each vial holding 10mg of the research compound. This product is manufactured exclusively for scientific investigation and in vitro laboratory experimentation.

Key Specifications at a Glance:

• Quantity: 10mg per vial, 10 vials per pack

• Form: Lyophilized (freeze-dried) powder

• Purity: ≥98% verified by third-party testing

• Molecular Formula: C₂₂₁H₃₆₆N₇₂O₆₇S

• Molecular Mass: 5135.9

• CAS Number: 218949-48-5

• Sequence: 44-amino acid GHRH analog with trans-3-hexenoic acid modification

• Synonyms: TH9507, Tesamorelin acetate

• Research Use Only: Not for human or animal consumption

Understanding TESA 10MG: The Research Context

TESA (Tesamorelin) is a synthetic 44-amino acid peptide analog of growth hormone-releasing hormone (GHRH). It was specifically engineered with a trans-3-hexenoic acid group at the N-terminus, a modification that confers enhanced resistance to enzymatic degradation compared to native GHRH. This structural enhancement makes TESA a more stable and durable research tool for studying the GHRH-GH-IGF-1 axis.

Key Research Interests:

• GHRH receptor (GHRHR) activation and signaling pathways

• Growth hormone (GH) and IGF-1 axis regulation

• Metabolic research and visceral adipose tissue studies

• Pituitary somatotroph function

• In vitro cell culture investigations

Researchers utilize TESA 10MG in controlled laboratory settings to study the growth hormone axis and its role in metabolic regulation. The peptide is of particular interest to investigators focused on endocrinology, metabolic disorders, and the fundamental mechanisms of GHRH receptor pharmacology.

The Significance of GHRH Research:
Growth hormone-releasing hormone (GHRH) is a hypothalamic peptide hormone that stimulates the synthesis and release of growth hormone from the anterior pituitary. The GHRH-GH-IGF-1 axis plays a critical role in:

• Growth and development

• Metabolic regulation and body composition

• Fat distribution, particularly visceral adipose tissue

• Cellular repair and regeneration

TESA serves as a stabilized research tool for studying this axis, offering enhanced stability over native GHRH for more consistent experimental results.

TESA 10MG Research Applications

TESA is used in various laboratory research contexts, primarily focused on endocrine signaling and metabolic regulation. Typical applications include:

GHRH Receptor (GHRHR) Signaling Studies:
The primary research interest in TESA revolves around its selective activation of GHRH receptors. Researchers use TESA to study:

• GHRHR binding affinity and activation kinetics

• Receptor signaling pathways (cAMP/PKA)

• GHRHR regulation and desensitization mechanisms

• Comparative studies with native GHRH and other analogs

Growth Hormone and IGF-1 Axis Research:
TESA stimulates physiologic GH secretion, making it valuable for:

• GH pulse dynamics studies

• IGF-1 production and regulation

• Feedback mechanisms in the GH/IGF-1 axis

• Age-related changes in GH secretion

Metabolic and Adipose Tissue Research:
TESA has been studied for its effects on metabolic parameters, particularly visceral adipose tissue. Research applications include:

• Visceral adiposity metabolism

• Lipid profile modulation

• Body composition studies in research models

• Metabolic syndrome pathways

Pituitary Cell Culture Studies:
Researchers use TESA in controlled cell culture systems to investigate:

• Somatotroph (GH-producing cell) function

• Pituitary cell signaling pathways

• GH synthesis and secretion dynamics

• GHRHR expression and regulation

GPCR Signaling Research:
The GHRH receptor is a prototypical class B GPCR. TESA serves as a research tool for:

• GPCR activation mechanisms

• Gs protein coupling and signaling

• Adenylyl cyclase activation

• cAMP response element (CRE) transcription

Third-Party Testing and Quality Assurance

Every batch of Premium TESA 10MG undergoes rigorous independent analytical testing to verify identity, purity, and consistency. This third-party testing ensures that researchers receive a product that meets strict quality specifications before it is approved for release.

The testing process includes:

• Identity verification through mass spectrometry

• Purity analysis using high-performance liquid chromatography (HPLC)

• Batch-to-batch consistency checks

• Residual solvent analysis to confirm complete lyophilization

With a verified purity of ≥98% as confirmed by HPLC, TESA 10MG meets the high standards required for serious laboratory research applications. Each vial contains only the lyophilized research compound with no unnecessary additives, fillers, or excipients. Batch‑specific Certificates of Analysis (CoA) are available upon request.

Chemical and Physical Properties

Molecular Characteristics

TESA is a 44-amino acid synthetic peptide with an N-terminal trans-3-hexenoic acid modification for enhanced stability.

Detailed Molecular Information:

• Molecular Formula: C₂₂₁H₃₆₆N₇₂O₆₇S

• Molecular Mass: 5135.9 daltons

• CAS Number: 218949-48-5

• Purity: ≥98% (HPLC)

• Appearance: White to off‑white lyophilized powder

Structural Features:

• 44-amino acid linear peptide

• N-terminal trans-3-hexenoic acid modification (DPP-IV resistance)

• Contains sulfur (cysteine residues)

• Full GHRH amino acid sequence preserved

The trans-3-hexenoic group at the N-terminus protects the peptide from dipeptidyl peptidase-IV (DPP-IV) degradation, giving it a longer half-life than native GHRH. This modification is crucial for maintaining stability in research applications.

Physical Form and Storage

The product is supplied as a lyophilized (freeze-dried) powder within a sterile, sealed vial. Lyophilization preserves the chemical integrity of the peptide by removing water content while maintaining the compound’s structure.

Recommended Storage Conditions:

• Store lyophilized powder at -20°C (-4°F) or below for long-term preservation

• Protect from light exposure

• Keep desiccated to prevent moisture absorption

• Allow vial to reach room temperature before opening to avoid condensation

• Avoid repeated freeze-thaw cycles once reconstituted

Stability Considerations:
Short-term storage (weeks) can be maintained at 0-4°C in a dry environment. For extended preservation, -20°C storage under dry conditions is recommended. Lyophilized products stored at -20°C have a shelf life of up to 24 months.

Once reconstituted with an appropriate sterile solvent, the solution should be used promptly according to laboratory protocols.

Intended Use and Regulatory Status

Research Use Only

TESA 10MG is classified as a research chemical and is intended exclusively for laboratory and in vitro experimentation. This designation means the product is sold strictly for:

• In vitro testing — experiments conducted in controlled laboratory environments

• Cell culture studies — investigating GHRH receptor signaling in pituitary cell lines

• Receptor binding assays — studying GHRHR interactions

• Endocrine research — investigating GH/IGF-1 axis regulation

• Metabolic research — studying lipid metabolism and body composition models

• Analytical research — chemical analysis and characterization studies

• Scientific investigation — basic research into GHRH analog structure and function

Important Regulatory Notice

This product is not a drug, food, cosmetic, or medical device. Bodily introduction of any kind into humans or animals is strictly forbidden by law. The product should only be handled by licensed, qualified professionals working in appropriate laboratory facilities.

The supplier is a chemical supplier, not a compounding pharmacy or outsourcing facility under Sections 503A or 503B of the Federal Food, Drug, and Cosmetic Act. All product information provided is for educational and research purposes only and does not constitute medical advice or clinical recommendations.

Handling and Safety Guidelines

Professional Handling Required

TESA 10MG should only be handled by trained laboratory personnel wearing appropriate personal protective equipment (PPE), including:

• Laboratory coat

• Nitrile gloves

• Safety goggles or face shield

• Appropriate respiratory protection if aerosolization is possible

Reconstitution Protocol

For laboratory use, the lyophilized powder should be reconstituted with a sterile, compatible solvent. Standard practice includes:

1. Allow the sealed vial to reach room temperature — approximately 15-30 minutes

2. Clean the rubber stopper with an alcohol swab

3. Add the calculated volume of solvent to achieve desired concentration

4. Gently swirl or roll the vial between palms — do not shake vigorously to avoid foaming

5. Allow complete dissolution before use — this typically takes 2-5 minutes

Reconstitution Example for TESA 10MG:
For researchers needing a 10mg/mL working solution, add 1mL of sterile solvent to the 10mg vial. For a 5mg/mL solution, add 2mL of solvent. For a 2mg/mL solution, add 5mL of solvent. Always verify calculations before proceeding with experiments.

Solvent Considerations:
TESA is water-soluble. Researchers should determine the appropriate solvent based on their specific experimental protocol. Common options include sterile water for injection, bacteriostatic water, or buffered solutions such as phosphate-buffered saline (PBS) at neutral pH.

Disposal Considerations

Dispose of TESA 10MG and any contaminated materials in accordance with federal, state, and local regulations for chemical waste disposal. Do not dispose of in regular trash or down drains unless permitted by local guidelines.

What Makes This Product Different

Enhanced Stability for Research Applications

Unlike native GHRH, which degrades rapidly, TESA incorporates a trans-3-hexenoic acid modification that protects the peptide from DPP-IV degradation. This enhanced stability allows researchers to achieve more consistent results across extended experimental timelines.

Well-Characterized Research Tool

TESA has been extensively studied in research settings, with well-defined pharmacokinetics and receptor pharmacology. This characterization provides researchers with a reliable reference material for GHRH receptor studies.

Optimal 10MG Research Quantity

The 10mg vial size is ideal for:

• Preliminary and pilot studies requiring smaller quantities

• Dose-finding experiments across multiple concentrations

• Precise handling for low-concentration protocols

• Cost-effective initial investigations before scaling up

Rigorous Quality Control

Unlike research chemicals sold without verification, TESA 10MG comes with documented third-party testing for every batch, including HPLC purity analysis and mass spectrometry identity verification. This commitment to quality assurance gives researchers confidence in the consistency and reliability of their experimental results. TESA 10mg

Batch Traceability

Each package of TESA 10MG includes batch identification numbers that allow researchers to trace their material back to original manufacturing and testing records. This traceability is essential for reproducible research and quality documentation. TESA 10mg

Frequently Asked Questions for Researchers

What is the purity level of TESA 10MG?

Each batch is tested to verify purity of ≥98% via HPLC, with identity confirmed by mass spectrometry. Individual certificates of analysis are available upon request.

What is the significance of the CAS number 218949-48-5?

The CAS number is a unique identifier for Tesamorelin, allowing researchers to verify they are working with the correct chemical compound when ordering or referencing the peptide in publications. TESA 10mg

What is the mechanism of action of TESA?

TESA is a GHRH analog that selectively binds to and activates GHRH receptors (GHRHR) on pituitary somatotroph cells, stimulating growth hormone synthesis and release.

How should the lyophilized powder be stored?

Store at -20°C or below, protected from light and moisture. Avoid repeated freeze-thaw cycles once reconstituted. Short-term storage (weeks) can be at 0-4°C.

What solvent should be used for reconstitution?

TESA is water-soluble. Researchers should determine the appropriate solvent based on their specific experimental protocol. Common options include sterile water for injection, bacteriostatic water, or buffered solutions such as PBS at neutral pH. TESA 10mg

Is this product sterile?

The lyophilized powder is manufactured under aseptic conditions, but researchers should follow standard laboratory practices for handling research chemicals. For cell culture applications, additional filtration using a 0.22-micron filter may be appropriate.

What research applications is TESA used for?

TESA is studied in GHRH receptor signaling, GH/IGF-1 axis regulation, metabolic research, visceral adipose tissue studies, and endocrine systems bench science in laboratory cell culture and research models. TESA 10mg

Can TESA be used in combination with other research peptides?

Researchers should determine compatibility based on their specific experimental design. Standard laboratory practice includes testing interactions in control experiments before full-scale implementation.

Final Notes for Laboratory Researchers

Premium TESA 10MG represents a high-purity research tool for qualified professionals conducting legitimate scientific investigations into GHRH receptor signaling, GH/IGF-1 axis regulation, metabolic pathways, and related endocrine fields. With documented third-party testing, complete chemical specifications, and appropriate packaging for laboratory use, this product meets the standards expected by serious researchers. TESA 10mg

The enhanced stability conferred by the trans-3-hexenoic acid modification makes TESA a more durable research tool than native GHRH, supporting consistent results across extended experimental timelines. The 10mg vial size is specifically optimized for smaller-scale experiments, preliminary studies, and research requiring precise handling.

For research use only. Not for human or animal consumption. Handle only in appropriate laboratory facilities with proper safety equipment and training. TESA 10mg